Pharmacologic Substance
methohexital
[ meth-oh-hek-si-tal ]
Brand Names:
Brevital
Effect:
Decreased Medullary Respiratory Drive; General Anesthesia; Increased Central Nervous System GABA Activity; Vasodilation
More Information:
Definitions related to methohexital:
-
A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.NCI ThesaurusU.S. National Cancer Institute, 2021
-
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
Return to OpenMD Medical Dictionary
> M
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.