Pharmacologic Substance
midostaurin
[ my-doh-staw-rin ]
Brand Names:
Rydapt
Effect:
Cellular Proliferation Alteration; Increased Cellular Death
May Treat:
Hematologic Neoplasms;
Leukemia, Myeloid, Acute;
Mastocytosis, Systemic
More Information:
Definitions related to midostaurin:
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A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.NCI ThesaurusU.S. National Cancer Institute, 2021
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