Pharmacologic Substance
midostaurin Audio
[ my-doh-staw-rin ]
Brand Names:
Rydapt
Effect:
Cellular Proliferation Alteration; Increased Cellular Death
May Treat:
Hematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to midostaurin:
  • A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.