Pharmacologic Substance
mirtazapine Audio
[ mir-ta-zuh-peen ]
Brand Names:
Mirataz; Remeron
Effect:
Increased Norepinephrine Activity; Increased Serotonin Activity
May Treat:
Depressive Disorder
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to mirtazapine:
  • A drug used to treat depression. It belongs to the family of drugs called antidepressant agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.
    NCI
    U.S. National Cancer Institute, 2021
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