Pharmacologic Substance
mitomycins
Subclass of:
Indolequinones; Azirines
Definitions related to mitomycins:
  • An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Group of methylazirinopyrroloindolediones obtained from Streptomyces strains; very toxic antibiotics used as antineoplastics in some solid tumors.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • (mitomycin antineoplastic antibiotic) Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.
    NCI
    U.S. National Cancer Institute, 2021
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