Pharmacologic Substance
mitotane Audio
[ my-toh-tane ]
Brand Names:
Lysodren
Effect:
Decreased Glucocorticoid Secretion
May Treat:
Adrenocortical Carcinoma; Cushing Syndrome
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to mitotane:
  • A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.