Pharmacologic Substance
mitoxantrone
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Multiple Sclerosis; Pain; Prostatic Neoplasms; Sarcoma
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to mitoxantrone:
  • 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl) -amino) ethyl)amino) anthraquinone; cytotoxic compound with potentially therapeutic antitumor activity in breast cancer, lymphoma, and leukemia.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
    NCI
    U.S. National Cancer Institute, 2021
  • An anthracenedione-derived antineoplastic agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.