Pharmacologic Substance
nabumetone
Brand Names:
Relafen
Effect:
Decreased Platelet Activating Factor Production; Decreased Prostaglandin Production; Decreased Renal K+ Excretion; Decreased Renal Na+ Excretion; Decreased Thromboxane Production
May Treat:
Arthritis, Rheumatoid;
Inflammation;
Osteoarthritis;
Pain
More Information:
Definitions related to nabumetone:
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A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation.NCI ThesaurusU.S. National Cancer Institute, 2021
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