Pharmacologic Substance
nelarabine
[ neh-lar-uh-been ]
Brand Names:
Arranon
Effect:
Decreased DNA Integrity; Decreased DNA Replication; Increased Cellular Death
May Treat:
Leukemia, T-Cell
More Information:
Definitions related to nelarabine:
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A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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