Antibiotic
netilmicin
Effect:
Decreased Protein Synthesis
May Treat:
Gram-Negative Bacterial Infections;
Staphylococcal Infections
Definitions related to netilmicin:
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A semisynthetic, water soluble aminoglycoside derived from sisomicin, a naturally occurring antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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