Neoplastic Process
neurofibroma
neu·ro·fi·bro·ma [ noo r-oh-fahy-broh-muh, nyoo r- ]
Subclass of:
Nerve Sheath Tumors
Etymology:
Greek neuron = a nerve + Latin fibra = fiber + Greek -oma = tumor
Definitions related to neurofibroma:
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A benign tumor that develops from the cells and tissues that cover nerves.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A rare benign peripheral nerve sheath tumor characterized by a well-demarcated intraneural or diffusely infiltrative extraneural space-occupying lesion consisting of Schwann cells, perineurial-like cells, and fibroblasts. It presents as a cutaneous nodule, a circumscribed mass in a peripheral nerve, a plexiform enlargement of a major nerve trunk, or with diffuse but localized involvement of skin and subcutaneous tissue. Multiple neurofibromas are typically associated with neurofibromatosis 1. Malignant transformation occurs almost exclusively in plexiform neurofibromas and neurofibromas of major nerves.OrphaNetINSERM, 2021
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An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.NCI ThesaurusU.S. National Cancer Institute, 2021
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Moderately firm, benign, encapsulated tumor resulting from proliferation of Schwann cells and fibroblasts that includes portions of nerve fibers; tumors usually develop along peripheral or cranial nerves and are a central feature of neurofibromatosis 1, where they may occur intracranially or involve spinal roots. pathologic features include fusiform enlargement of the involved nerve.CRISP ThesaurusNational Institutes of Health, 2006
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A neurofibroma is a type of nerve tumor that forms soft bumps on or under the skin. A neurofibroma can develop within a major or minor nerve anywhere in the body. This common type of benign nerve tumor tends to form more centrally within the nerve. Sometimes it arises from several nerve bundles (plexiform neurofibroma).Mayo Foundation for Medical Education and Research
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A neurofibroma is a non-cancerous (benign) tumor that develops from the cells and tissues that cover nerves. Some people who develop neurofibromas have a genetic condition known as neurofibromatosis (NF). There are different types of NF, but type 1 is the most common.National Center for Advancing Translational Sciences
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