Immunologic Factor
nivolumab
Brand Names:
Opdivo
Effect:
Increased Lymphocyte Cell Production
May Treat:
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Squamous Cell;
Kidney Neoplasms;
Lymphoma;
Melanoma;
Urinary Bladder Neoplasms
More Information:
Definitions related to nivolumab:
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A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, nivolumab binds to and blocks the activation of PD-1, an immunoglobulin superfamily (IgSF) transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This results in the activation of T-cells and cell-mediated immune responses against tumor cells. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.NCI ThesaurusU.S. National Cancer Institute, 2021
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A genetically engineered, fully humanized immunoglobulin G4 monoclonal antibody that binds to the PD-1 RECEPTOR, activating an immune response to tumor cells. It is used as monotherapy or in combination with IPILIMUMAB for the treatment of advanced malignant MELANOMA. It is also used in the treatment of advanced or recurring NON-SMALL CELL LUNG CANCER; RENAL CELL CARCINOMA; and HODGKIN'S LYMPHOMA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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