Pharmacologic Substance
nortriptyline
[ nawr-trip-tuh-leen ]
Brand Names:
Pamelor
Effect:
Decreased Serotonin Degradation; Increased Central Nervous System Norepinephrine Activity
May Treat:
Anxiety Disorders;
Attention Deficit Disorder with Hyperactivity;
Depressive Disorder;
Enuresis;
Pain
More Information:
Definitions related to nortriptyline:
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A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.NCI ThesaurusU.S. National Cancer Institute, 2021
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Tricyclic antidepressant of the dibenzocycloheptadiene class used to treat symptoms of depression and to relieve chronic, severe pain.CRISP ThesaurusNational Institutes of Health, 2006
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