Immunologic Factor
olaratumab
Brand Names:
Lartruvo
Effect:
Cellular Proliferation Alteration
May Treat:
Sarcoma
Definitions related to olaratumab:
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A fully human IgG1 monoclonal antibody directed against the platelet-derived growth factor receptor alpha (PDGFR alpha) with potential antineoplastic activity. Anti-PDGFR alpha monoclonal antibody IMC-3G3 selectively binds to PDGFR alpha,.blocking the binding of its ligand, PDGF; signal transduction downstream of PDGFR through the MAPK and PI3K pathways is inhibited, which may result in inhibition of angiogenesis and tumor cell proliferation. Overexpressed by various cancer cell types, PDGFR is a transmembrane protein tyrosine kinase receptor, consisting of isoforms A and B that is important in regulating cellular growth and differentiation and angiogenesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance being studied in the treatment of glioblastoma (a type of brain tumor) that has come back. It binds to receptors for a protein called platelet-derived growth factor (PDGF). This keeps PDGF from binding to the cells. This may stop the growth of cancer cells and blood vessels that have the receptors for PDGF. It is a type of monoclonal antibody.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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