Pharmacologic Substance
oltipraz
[ ol-tih-praz ]
Definitions related to oltipraz:
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A drug used in cancer prevention.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.NCI ThesaurusU.S. National Cancer Institute, 2021
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Pyrazine with antiviral, schistosomicidal and anticarcinogenic properties.CRISP ThesaurusNational Institutes of Health, 2006
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