Pharmacologic Substance
omeprazole Audio
[ oh-mep-ruh-zohl ]
Brand Names:
Prilosec; Talicia; UlcerGard; Yosprala; Zegerid Reformulated Aug 2006
Effect:
Inhibition Gastric Acid Secretion
May Treat:
Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Helicobacter Infections; Stomach Ulcer; Zollinger-Ellison Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to omeprazole:
  • A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.
    NCI
    U.S. National Cancer Institute, 2021
  • A drug that inhibits gastric acid secretion.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Substituted benzimidazole used as a gastric acid secretion inhibitor.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.