Pharmacologic Substance
orantinib
Definitions related to orantinib:
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A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called angiogenesis inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An orally bioavailable receptor tyrosine kinase inhibitor. SU6668 binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. SU6668 also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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