Pharmacologic Substance
orlistat
Brand Names:
Alli; Xenical
Effect:
Inhibition Fat Digestion
May Treat:
Obesity
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to orlistat:
  • A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A reversible active-site inhibitor of gastrointestinal lipases. Orlistat forms a covalent bond with the active serine site in gastric and pancreatic lipases, thereby inhibiting their activity and preventing dietary fat from being hydrolyzed and absorbed. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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