A chronic condition in which both the breakdown and regrowth of bone are increased. Paget disease of bone occurs most frequently in the pelvic and leg bones, skull, and lower spine. It is most common in older individuals, and may lead to bone pain, deformities, and fractures.

A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.

(bone paget disease) A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.

Disease marked by repeated episodes of increased bone resorption followed by excessive repair, resulting in weakened, deformed bones of increased mass.

(paget's disease of bone) Paget's disease of bone is a chronic bone disorder. Normally, there is a process in which your bones break down and then regrow. In Paget's disease, this process is abnormal. There is excessive breakdown and regrowth of bone. Because the bones regrow too quickly, they are bigger and softer than normal. They may be misshapen and easily fractured (broken). Paget's usually affects just one or a few bones. Researchers do not know for sure what causes Paget's disease. Environmental factors may play a role. In some cases, the disease runs in families, and several genes have been linked to the disease. The disease is more common in older people and those of northern European heritage. If you have a close relative who has Paget's, you are much more likely to have it. Many people do not know that they have Paget's, because it often has no symptoms. When there are symptoms, they are similar to those of arthritis and other disorders. The symptoms include: Pain, which may be due to the disease or to arthritis, which can be a complication of Paget's; Headaches and hearing loss, which can happen when Paget's disease affects the skull; Pressure on the nerves, which can happen when Paget's disease affects the skull or spine; Increased head size, bowing of a limb, or curvature of the spine. This can happen in advanced cases.; Hip pain, if Paget's disease affects the pelvis or thighbone; Damage to the cartilage of your joints, which may lead to arthritis. Usually, Paget's disease gets worse slowly over time. It does not spread to normal bones. Paget's disease can lead to other complications, such as: Arthritis, because the misshapen bones can cause increased pressure and more wear and tear on the joints; Heart failure. In severe Paget's disease, the heart has to work harder to pump blood to affected bones. Heart failure is more likely if you also have hardening of the arteries.; Kidney stones, which can happen when the excessive breakdown of the bone leads to extra calcium in the body; Nervous system problems, since the bones can cause pressure on the brain, spinal cord, or nerves. There may also be reduced blood flow to the brain and spinal cord.; Osteosarcoma, cancer of the bone; Loose teeth, if Paget's disease affects the facial bones; Vision loss, if Paget's disease in the skull affects the nerves. This is rare. Your health care provider may use many tools to make a diagnosis: A medical history, which includes asking about your symptoms; A physical exam; An x-ray of the affected bones. Paget's disease is almost always diagnosed using x-rays.; An alkaline phosphatase blood test; A bone scan. Sometimes the disease is found by accident when one of these tests is done for another reason. To avoid complications, it is important to find and treat Paget's disease early. The treatments include: Medicines. There are several different medicines to treat Paget's disease. The most common type is bisphosphonates. They help reduce bone pain and stop or slow down the progress of the disease.; Surgery is sometimes needed for certain complications of the disease. There are surgeries to Allow fractures (broken bones) to heal in a better position; Replace joints such as the knee and hip when there is severe arthritis; Realign a deformed bone to reduce the pain in weight-bearing joints,...

Paget disease of bone is a chronic disorder of the adult skeleton in which bone turnover is accelerated in localized areas. Normal matrix is replaced with softened and enlarged bone. The disease may be asymptomatic or cause gradual onset of bone pain or deformity. Diagnosis is by x-ray. Treatment includes symptomatic measures and often...

Paget's disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become fragile and misshapen. Paget's disease of bone most commonly occurs in the pelvis, skull, spine and legs.

Paget disease of bone is a disorder that involves abnormal bone destruction and regrowth, which results in deformity. This condition can affect any of the bones in the body; but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones; but it does not affect the entire...

A chronic bone disorder that is characterized by focal areas of increased bone remodeling, resulting in overgrowth of poorly organized bone. This unbalanced process may lead to osseous deformities, altered joint biomechanics, nerve compressions, and pathologic fractures.

Paget disease of bone, chronic disease of middle age, characterized by excessive breakdown and formation of bone tissue. It is a localized disease that may be unifocal, affecting a single bone, or multifocal, affecting many bones or nearly the entire skeleton. For this reason, it is included among...