Vitamin
paricalcitol Audio
[ payr-ih-kal-sih-tol ]
Brand Names:
Zemplar
Effect:
Decreased PTH Secretion
May Prevent:
Hyperparathyroidism
May Treat:
Hyperparathyroidism
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to paricalcitol:
  • A substance that is being used to treat overactive parathyroid glands in patients with kidney failure. It is also being studied in the treatment of cancer. Paricalcitol belongs to the family of drugs called vitamin D analogs.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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