Immunologic Factor
pegfilgrastim Audio
[ peg-fil-gras-tim ]
Brand Names:
Fulphila; Neulasta; Nyvepria; Udenyca; Ziextenzo
Effect:
Increased Granulocytic Cell Production
May Prevent:
Infections; Neutropenia
May Treat:
Neutropenia
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to pegfilgrastim:
  • A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.