Immunologic Factor
pegfilgrastim
[ peg-fil-gras-tim ]
Brand Names:
Fulphila; Neulasta; Nyvepria; Udenyca; Ziextenzo
Effect:
Increased Granulocytic Cell Production
May Prevent:
Infections; Neutropenia
May Treat:
Neutropenia
More Information:
Definitions related to pegfilgrastim:
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A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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