Organic Chemical
pelitrexol
Definitions related to pelitrexol:
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation
    NCI
    U.S. National Cancer Institute, 2021
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