Pharmacologic Substance
pemetrexed
Brand Names:
Alimta
Effect:
Decreased DNA Integrity; Decreased Protein Synthesis
May Treat:
Carcinoma, Non-Small-Cell Lung; Neoplasms, Mesothelial
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to pemetrexed:
  • A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.