Pharmacologic Substance
pemetrexed
Brand Names:
Alimta
Effect:
Decreased DNA Integrity; Decreased Protein Synthesis
May Treat:
Carcinoma, Non-Small-Cell Lung;
Neoplasms, Mesothelial
More Information:
Definitions related to pemetrexed:
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A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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