Immunologic Factor
pertuzumab
[ per-too-zoo-mab ]
Brand Names:
Perjeta; Phesgo
Effect:
Increased Cellular Death
May Treat:
Breast Neoplasms
More Information:
Definitions related to pertuzumab:
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A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A monoclonal antibody that is being studied in the treatment of cancer. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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