Pathologic Function
philadelphia chromosome Audio
Phil·a·del·phi·a chro·mo·some [ fih-luh-del-fee-uh kroh-muh-some ]
Subclass of:
Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 9; Chromosomal translocation
Definitions related to philadelphia chromosome:
  • A translocation between chromosomes 9 and 22. It is the hallmark for chronic myelogenous leukemia (CML).
    NCI
    U.S. National Cancer Institute, 2021
  • An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it. Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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