Pharmacologic Substance
pioglitazone
[ py-oh-glih-tuh-zone ]
Brand Names:
Actoplus Met; Actos; Duetact; Oseni
Effect:
Increased Glucose Transport into Cells; Increased Glycolysis
May Treat:
Diabetes Mellitus, Type 2
More Information:
Definitions related to pioglitazone:
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A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.NCI ThesaurusU.S. National Cancer Institute, 2021
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