Pharmacologic Substance
pioglitazone Audio
[ py-oh-glih-tuh-zone ]
Brand Names:
Actoplus Met; Actos; Duetact; Oseni
Effect:
Increased Glucose Transport into Cells; Increased Glycolysis
May Treat:
Diabetes Mellitus, Type 2
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to pioglitazone:
  • A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.