Pharmacologic Substance
piperazine
pi·per·a·zine [ pi-per-uh-zeen, -zin ]
Brand Names:
Excel Roundworm De Wormer; Pro Pet De Wormer
Effect:
Increased Muscular System GABA Activity
May Treat:
Ascariasis;
Enterobiasis;
Nematode Infections
More Information:
Definitions related to piperazine:
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A cyclic organic compound possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring that serves as a backbone for piperazine derivatives and acts as a gamma-amino-butyric acid (GABA) receptor agonist in nematodes, with potential anti-helminthic activity. Upon administration, piperazine binds to the GABA inhibitory receptors in susceptible nematodes, thereby inducing chloride channel opening and hyperpolarization. This results in paralysis of the worm musculature and allows normal peristalsis to dislodge the worm from the intestinal lumen, which causes the worm to be expelled from the body. Unlike vertebrates where GABA is restricted to the central nervous system (CNS), the GABA receptors in helminths are also expressed in the peripheral nervous system.NCI ThesaurusU.S. National Cancer Institute, 2021
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An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Saturated 6-membered ring structure with 2 nitrogen atoms.CRISP ThesaurusNational Institutes of Health, 2006
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Piperazine, anthelmintic drug used in the treatment of intestinal roundworm infection in humans and domestic animals (including poultry) and against pinworm infection in humans. It is administered orally, in repeated doses, usually as the citrate salt. Its action causes worms to be paralyzed and...Encyclopedia Britannica, Inc., 2020
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