Pharmacologic Substance
pirfenidone
[ peer-feh-nih-done ]
Brand Names:
Esbriet
Effect:
Decreased Growth Factor Activity
May Treat:
Pulmonary Fibrosis
More Information:
Definitions related to pirfenidone:
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A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy. It belongs to the family of drugs called anti-inflammatory agents.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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