Pharmacologic Substance
primidone
Brand Names:
Mysoline
Effect:
Neurotransmitter & Neuromuscular Transmitter Activity Alteration
May Treat:
Epilepsies, Partial;
Epilepsy, Tonic-Clonic;
Tremor
More Information:
Definitions related to primidone:
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A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties.NCI ThesaurusU.S. National Cancer Institute, 2021
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