Gene or Genome
proto-oncogene
[ proh-toh-ong-kuh-jeen ]
Subclass of:
Oncogenes
Definitions related to proto-oncogenes:
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(protooncogene) Normal, nonpathogenic genes which, when mutated or otherwise altered, become oncogenes; many code for growth factors, growth factor receptors, genetic regulatory proteins, or other signal transduction molecules; compare with TUMOR SUPPRESSOR GENE and ONCOGENE.CRISP ThesaurusNational Institutes of Health, 2006
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A gene involved in normal cell growth. Mutations (changes) in a proto-oncogene may cause it to become an oncogene, which can cause the growth of cancer cells.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in the control of cell proliferation or differentiation. Mutations, amplifications or rearrangements of proto-oncogenes lead to upregulated or deregulated cell growth and allow them to function as oncogenes.NCI ThesaurusU.S. National Cancer Institute, 2021
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Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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