Pharmacologic Substance
pyroxamide Audio
[ py-rok-suh-mide ]
Definitions related to pyroxamide:
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called histone deacetylase inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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