Pharmacologic Substance
rosiglitazone
Brand Names:
Avandamet; Avandia
Effect:
Increased Glucose Transport into Cells; Increased Glycolysis
May Treat:
Diabetes Mellitus, Type 2
More Information:
Definitions related to rosiglitazone:
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A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its selective affinity for peroxisome proliferator-activated receptor (PPAR) gamma and its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks.NCI ThesaurusU.S. National Cancer Institute, 2021
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Peroxisome proliferator activated receptor agonist; reduces lipid availability; improves insulin action and glucoregulation.CRISP ThesaurusNational Institutes of Health, 2006
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The active ingredient in a drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Rosiglitazone stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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