Pharmacologic Substance
rosiglitazone maleate
[ roh-sig-lih-tuh-zone may-lee-ayt ]
Effect:
Increased Glucose Transport into Cells; Increased Glycolysis
May Treat:
Diabetes Mellitus, Type 2
More Information:
Definitions related to rosiglitazone maleate:
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A drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Avandia stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.NCI ThesaurusU.S. National Cancer Institute, 2021
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