Antibiotic
sabarubicin
Definitions related to sabarubicin:
  • A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin.
    NCI
    U.S. National Cancer Institute, 2021
  • An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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