Pharmacologic Substance
safingol
[ sa-fin-gol ]
Definitions related to safingol:
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A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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