Organic Chemical
safrole
saf·role [ saf-rohl ]
More Information:
ChemID; DailyMed; PDR
Definitions related to safrole:
  • A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A naturally-occurring, colorless to slightly yellow liquid that is soluble in ethanol, ether, and chloroform. Safrole is no longer used in the United States. Minimal exposure to safrole may occur through the use of edible spices, including nutmeg and mace, which contain low levels of this compound. It is reasonably anticipated to be a human carcinogen. (NCI05)
    NCI
    U.S. National Cancer Institute, 2021
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