Immunologic Factor
sargramostim
[ sar-gra-moh-stim ]
Brand Names:
Leukine
Effect:
Increased Cytokine Production
May Treat:
Breast Neoplasms;
Hodgkin Disease;
Lymphoma, Non-Hodgkin;
Neutropenia;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
More Information:
Definitions related to sargramostim:
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A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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