Congenital Abnormality
sclerema neonatorum
Subclass of:
Skin Abnormalities; Neonatal disorder
Definitions related to sclerema neonatorum:
  • A diffuse hardening of skin and subcutaneous adipose tissue, associated with minimal inflammation without fat necrosis, that typically affects critically ill preterm neonates during the first week of life.
    NCI
    U.S. National Cancer Institute, 2021
  • A severe, sometimes fatal, disorder of adipose tissue occurring chiefly in preterm or debilitated infants suffering from an underlying illness and manifested by a diffuse, nonpitting induration of the affected tissue. The skin becomes cold, yellowish, mottled, and inflexible.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The classic description of sclerema neonatorum (SN) is credited to Underwood, who described it in 1784 and appropriately termed it
    Medscape
    WebMD, 2025
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