Pharmacologic Substance
semustine
[ seh-mus-teen ]
Subclass of:
Lomustine
Definitions related to semustine:
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4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An anticancer drug that belongs to the family of drugs called alkylating agents.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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