Pharmacologic Substance
seocalcitol Audio
[ see-oh-kal-sih-tol ]
Definitions related to seocalcitol:
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called vitamin D analogs.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.
    NCI
    U.S. National Cancer Institute, 2021
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