Pharmacologic Substance
sildenafil citrate
sil·den·a·fil cit·rate
Effect:
Penile Venous Vasodilation; Pulmonary Venous Vasodilation
May Treat:
Hypertension, Pulmonary;
Impotence, Vasculogenic
More Information:
Definitions related to sildenafil citrate:
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A drug used to treat erectile dysfunction. Viagra relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The active ingredient in Viagra. It blocks the breakdown of cyclic guanosine monophosphate, a chemical necessary for an erection.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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The citrate salt form of sildenafil, an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production.NCI ThesaurusU.S. National Cancer Institute, 2021
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