Pharmacologic Substance
silver sulfadiazine
sil·ver sul·fa·di·a·zine
Brand Names:
Baytril Otic; Silvadene; SSD; Thermazene
Effect:
Cell Membrane Alteration; Cell Wall Alteration
May Prevent:
Wound Infection
May Treat:
Wound Infection
More Information:
Definitions related to silver sulfadiazine:
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A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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Antibacterial used topically in burn therapy.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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