Pharmacologic Substance
simvastatin
[ sim-vuh-stat-n, sim-vuh-stat-n ]
Brand Names:
Flolipid; Vytorin; Zocor
May Prevent:
Coronary Artery Disease
May Treat:
Coronary Artery Disease;
Hypercholesterolemia;
Hyperlipoproteinemias;
Hypertriglyceridemia
More Information:
Definitions related to simvastatin:
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A derivative of lovastatin and inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG coA reductase), a rate limiting enzyme in the biosynthesis of cholesterol.CRISP ThesaurusNational Institutes of Health, 2006
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A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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