Immunologic Factor
siplizumab Audio
[ sip-lih-zoo-mab ]
Definitions related to siplizumab:
  • A humanized monoclonal immunoglobulin G1 antibody with potential antineoplastic activity. Siplizumab binds to CD2, a specific receptor found in T cells and NK cells, thereby triggering a host immune response that results in lysis of CD2+ cells, selective suppression of the immune system, and control of activated T cell growth.
    NCI
    U.S. National Cancer Institute, 2021
  • A monoclonal antibody that is being studied in the treatment of certain lymphoproliferative disorders and psoriasis.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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