Genetic Function
site-directed mutagenesis
Subclass of:
Protein Engineering
Definitions related to mutagenesis, site-directed:
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(targeted mutation) A mutation created in a gene at a specific location. Targeted mutations are frequently generated in the laboratory to investigate the influence of inactivation of a particular gene product.NCI ThesaurusU.S. National Cancer Institute, 2021
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(site-directed mutagenesis) Any of several methods used to create alterations in a gene at a specific location.NCI ThesaurusU.S. National Cancer Institute, 2021
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(site directed mutagenesis) Mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule; the most common method involves use of a chemically synthesized oligonucleotide mutant which can hybridize with the DNA target molecule; the resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered.CRISP ThesaurusNational Institutes of Health, 2006
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Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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