Pharmacologic Substance
sodium selenite
so·di·um sel·e·nite
More Information:
ChemID; DailyMed; PDR
Definitions related to sodium selenite:
  • An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.
    NCI
    U.S. National Cancer Institute, 2021
  • The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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