Pharmacologic Substance
sodium thiosulfate Audio
so·di·um thi·o·sul·fate [ soh-dee-um thy-oh-sul-fayt ]
Brand Names:
Exoderm; Versiclear
May Prevent:
Drug-Related Side Effects and Adverse Reactions
May Treat:
Arsenic Poisoning; Tinea Versicolor
More Information:
ChemID; DailyMed; PDR
Definitions related to sodium thiosulfate:
  • A substance that is used in medicine as an antidote to cyanide poisoning and to decrease side effects of the anticancer drug cisplatin.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.