Pharmacologic Substance
sodium thiosulfate
so·di·um thi·o·sul·fate [ soh-dee-um thy-oh-sul-fayt ]
Brand Names:
Exoderm; Versiclear
May Prevent:
Drug-Related Side Effects and Adverse Reactions
May Treat:
Arsenic Poisoning;
Tinea Versicolor
More Information:
Definitions related to sodium thiosulfate:
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A substance that is used in medicine as an antidote to cyanide poisoning and to decrease side effects of the anticancer drug cisplatin.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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