Pharmacologic Substance
sofosbuvir
Brand Names:
Epclusa; Harvoni; Sovaldi; Vosevi
May Treat:
Hepatitis C, Chronic
More Information:
Definitions related to sofosbuvir:
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A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.NCI ThesaurusU.S. National Cancer Institute, 2021
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