Pharmacologic Substance
sorafenib
Brand Names:
Nexavar
Effect:
Cellular Proliferation Alteration
May Treat:
Carcinoma, Hepatocellular;
Carcinoma, Renal Cell;
Thyroid Neoplasms
More Information:
Definitions related to sorafenib:
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A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Sorafenib stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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