Pharmacologic Substance
sorafenib tosylate Audio
[ sor-a-feh-nib toh-suh-layt ]
Effect:
Cellular Proliferation Alteration
May Treat:
Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Thyroid Neoplasms
Definitions related to sorafenib tosylate:
  • A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.