Pharmacologic Substance
staurosporine
[ staw-roh-spor-een ]
Subclass of:
Indole Alkaloids;
Carbazoles
Definitions related to staurosporine:
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A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective inhibitor of protein kinases, including protein kinase C. This agent induces apoptosis by an undetermined mechanism.NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug that belongs to the family of drugs called alkaloids. It is being studied in the treatment of cancer.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Exhibits cytotoxic or antitumor properties; naturally derived from cultures of Streptomyces; inhibits protein kinase C.CRISP ThesaurusNational Institutes of Health, 2006
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